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Jeff Hermes, Ph.D., former Kallyope, Roche, and Merck R&D leader, joins as Executive Vice President of Enabling Sciences

Natalie Dales, Ph.D., promoted to Chief of Research Operations and Portfolio Strategy

Boston, Mass., November 9, 2022 — Odyssey Therapeutics, Inc., a biotechnology company pioneering next generation precision immunomodulators and oncology medicines, today announced the appointment of Jeff Hermes, Ph.D., as Executive Vice President of Enabling Sciences and promotion of Natalie Dales, Ph.D., to the newly created position of Chief of Research Operations and Portfolio Strategy. In these roles, Dr. Hermes will oversee capability development and implementation for Odyssey’s platform approaches and technologies, and Dr. Dales will drive scientific strategy and facilitate collaboration across the organization.

“I am pleased to welcome Jeff and Natalie into their new positions as I believe they will contribute greatly to the company during this period of rapid growth,” said Gary D. Glick, Ph.D., Founder and Chief Executive Officer of Odyssey Therapeutics. “Jeff’s leadership in screening, pharmacology, and translational sciences, as well as his experience across the drug discovery process, will be invaluable as we continue to create the next generation of transformative medicines for patients suffering from severe immunology and oncology diseases. Additionally, Natalie has played a critical role in helping shape Odyssey’s research programs and strategy during her time here, and she will continue to deliver upon our portfolio strategy and streamline efforts across the company.”

Dr. Hermes will be responsible for advancing the company’s proteomics, small molecule hit-finding platforms, and transcription factor capabilities to discover next generation medicines. Dr. Dales will drive scientific strategy and decision making to advance the pipeline through clinical entry, create connectivity and cohesion between programs and capabilities, and oversee resource utilization to drive efficiency and synergies across the organization.

Jeff Hermes, Ph.D., Executive Vice President of Enabling Sciences

Dr. Hermes is a seasoned professional with more than 30 years’ experience in biochemistry, pharmacology, and in vitro sciences in the biopharmaceutical industry. Most recently, Dr. Hermes served as the Vice President of In Vitro Pharmacology at Kallyope, where he led in vitro pharmacology, screening, and enzymology efforts to create transformational small molecule therapeutics that act on the gut-brain axis. Previously, he was Head of Screening and Translational Enzymology at Roche where he was responsible for guiding early-stage efforts from discovery through development candidate nomination. Prior to Roche, Dr. Hermes spent over 25 years at Merck and ultimately served as Executive Director and Head of Screening and Protein Sciences, where he oversaw hit-finding, lead identification, and translational science efforts across diverse therapeutic areas. He received his Ph.D. degree at the University of Wisconsin-Madison and completed postdoctoral training at Harvard University. 

Natalie Dales, Ph.D., Chief of Research Operations and Portfolio Strategy

Dr. Dales brings over 20 years of experience leading small molecule drug discovery in pharmaceuticals and biotech. Dr. Dales most recently served as Odyssey’s Executive Vice President of Enabling Sciences. Previously, she spent over 15 years at Novartis, where she held roles of increasing responsibility including Executive Director and Head of Portfolio and Strategy for Global Discovery Chemistry. Prior to this role, she led small molecule drug discovery efforts focused on liver, kidney, hematology, oncology and rare diseases. She was also a senior advisor for the Novartis Genesis Labs, an internal innovation incubator which fostered and funded disruptive concepts to accelerate drug discovery.

About Odyssey Therapeutics

Odyssey Therapeutics is a biotechnology company focused on discovering, developing and commercializing the next generation of immunomodulators and oncology medicines. Composed of an expert team of drug hunters, scientists and industry leaders in foundational biology, chemistry, and data sciences, Odyssey is transforming drug discovery to accelerate and drive the creation and efficient delivery of life-enhancing precision medicines to patients. For more information, please visit http://www.odysseytx.com/ and follow Odyssey Therapeutics on Twitter (@Odyssey_Tx) and LinkedIn.

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Nick Paul Taylor

The Odyssey Therapeutics story is progressing quickly. Ten months after disclosing a $218 million series A, the Gary Glick-helmed biotech is back with another mega round as it prepares to push candidates into clinic-enabling studies next year. 

Glick, Ph.D., who made his name setting up and running biotechs such as Lycera, IFM Ther­a­peu­tics and Scorpion Therapeutics, founded Odyssey in 2021 and rounded up a deep-pocketed syndicate of investors to support his plans. By the time Glick publicly unveiled Odyssey late last year, the biotech had raised $218 million and built a 100-person team to advance seven candidates toward the clinic.

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John Carroll

If there’s one thing Gary Glick excels at, it’s raising money for his startups. Even in this soured financial environment.

No sooner had he closed his whopping big launch round for Odyssey Therapeutics — announcing it late last year with $218 million brimming in his coffers — than he was off and running on the Series B. And today he’s taking the wraps off of the added cash — all $168 million.

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Cormac Sheridan

Odyssey Therapeutics Inc. closed a hefty $168 million series B round to progress multiple small-molecule and protein-based drug discovery and development programs in autoimmune disease and cancer.

The Boston-based company landed with a splash last year, raising $218 million in a series A round and setting out ambitions to unleash next-generation chemistry, structural biology and computational approaches on a broad range of undrugged targets, typically upstream signaling nodes that control pathways considered to be important disease drivers.

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— Financing led by General Catalyst, with participation from all existing investors and new leading institutional investors and mutual funds —

— Proceeds to advance Odyssey’s broad portfolio of precision immunomodulators and oncology medicines —

Boston, Mass., October 13, 2022 – Odyssey Therapeutics, Inc., a biotechnology company pioneering next generation precision immunomodulators and oncology medicines, today announced a $168 million Series B financing. This funding, which follows Odyssey’s $218 million Series A announced in December 2021, brings the total capital raised to $386 million. The proceeds will enable Odyssey to advance its portfolio of precision immunomodulators and oncology medicines in support of its mission of developing innovative medicines to treat serious human diseases.

The Series B was led by General Catalyst, a leading global venture capital firm and active investor in the healthcare sector. Other new investors participating in the Series B financing include funds and accounts advised by Fidelity Management & Research Company, funds and accounts advised by T. Rowe Price Associates, Inc., GreatPoint Ventures, Catalio Capital Management, Walleye Capital, Alexandria Venture Investments, The Healthcare Innovation Investment Fund LLC, an investment fund associated with SVB Securities LLC, and other institutional investors. The financing also includes participation from all Series A investors including OrbiMed, SR One, Foresite Capital, Logos Capital, Woodline Partners LP, HBM Healthcare Investments, Colt Ventures and Creacion Ventures.

“Odyssey is pioneering next generation therapeutics by marrying a powerful drug discovery engine integrating machine learning, biology, and medicinal and structural chemistry with an exceptional leadership team of proven drug developers. We are pleased to partner with General Catalyst and our world-class syndicate of investors and believe the interest in our immunology and oncology pipeline and capabilities further validates our approach to therapeutic development,” said Gary D. Glick, Ph.D., Founder and Chief Executive Officer of Odyssey Therapeutics. “We have made tremendous strides since our launch in 2021, and we value the support as we advance multiple candidates into IND-enabling studies in 2023.”

“At General Catalyst, we are committed to investing in companies driving powerful, positive and enduring change, and Odyssey’s unyielding commitment to improving the lives of patients by targeting the underlying causes of serious inflammatory diseases and cancer aligns with our mission,” said Elena Viboch, Partner at General Catalyst. “We are confident in Odyssey’s vision, proven leadership and ability to pioneer and develop next generation therapeutics through their integrated platform approach, and we look forward to seeing Odyssey work toward achieving their mission of delivering life-enhancing medicines to patients in need.”

“I am delighted to welcome our new Series B investors,” said Jeff Leiden, M.D., Ph.D., Chairman of the Odyssey Board. “Their investment along with Odyssey’s unique combination of experienced and talented drug hunters, new technologies and a broad and deep pipeline of novel targets will accelerate our discovery and development of life-enhancing medicines for patients in need.”

Odyssey’s immunology and oncology portfolio encompasses eight declared programs initially focused on small molecule and protein therapeutics. In addition, Odyssey is building an industry leading discovery engine that integrates artificial intelligence and machine learning for molecular design; a chemistry platform encompassing proprietary covalent libraries targeting multiple amino acids, molecular glues and natural products; and a functional genomics platform for novel target discovery. 

About Odyssey Therapeutics

Odyssey Therapeutics is a biotechnology company focused on discovering, developing and commercializing the next generation of immunomodulators and oncology medicines. Composed of an expert team of drug hunters, scientists and industry leaders in foundational biology, chemistry, and data sciences, Odyssey is transforming drug discovery to accelerate and drive the creation and efficient delivery of life-enhancing precision medicines to patients. For more information, please visit www.odysseytx.com and follow Odyssey Therapeutics on Twitter (@Odyssey_Tx) and LinkedIn.

About General Catalyst

General Catalyst is a venture capital firm that invests in powerful, positive change that endures — for our entrepreneurs, our investors, our people, and society. We support founders with a long-term view who challenge the status quo, partnering with them from seed to growth stage and beyond to build companies that withstand the test of time. With offices in San Francisco, Palo Alto, New York City, London, and Boston, the firm has helped support the growth of businesses such as: Airbnb, Deliveroo, Guild, Gusto, Hubspot, Illumio, Lemonade, Livongo, Oscar, Samsara, Snap, Stripe, and Warby Parker. For more: www.generalcatalyst.com.

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Boston, Mass., September 22, 2022 — Odyssey Therapeutics, Inc., a biotechnology company pioneering next generation precision immunomodulators and oncology medicines, today announced that it is has been named by Endpoints News as one of the Endpoints 11 companies of 2022. This honor is awarded to the most promising private biotechnology companies in the industry breaking new ground in drug development.

Odyssey’s highly integrated drug hunting engine fuses both established and newly-emerging drug discovery technologies to tackle immunology and oncology targets with the highest clinical and commercial potential, including those previously considered “undruggable.” The company’s platform approach aims to transform drug discovery to accelerate and drive the creation and efficient delivery of life-enhancing precision medicines to patients. 

“We are honored to be recognized as an Endpoints 11 company for our suite of cutting-edge technology platforms and portfolio of innovative product candidates to deliver differentiated patient benefits with an eye to transforming standards of care,” said Gary D. Glick, Ph.D., Founder and Chief Executive Officer of Odyssey Therapeutics. “This recognition serves as a testament to the tireless work and dedication of our team in delivering on our mission to provide life-changing solutions for patients, and continues to fuel our urgency to go beyond the current limitations of treatment and make the future of precision medicine a reality.”

About Odyssey Therapeutics

Odyssey Therapeutics is a biotechnology company dedicated to discovering, developing and commercializing immunomodulators and oncology medicines that aim to transform drug discovery to accelerate and drive the creation and efficient delivery of life-enhancing precision medicines to patients. Built from the ground-up by an expert team of drug hunters, scientists and industry leaders, Odyssey is focused on being first to market with programs that act on targets with the highest clinical and commercial potential. For more information, please visit www.odysseytx.com and follow Odyssey Therapeutics on Twitter (@Odyssey_Tx) and LinkedIn.

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